What does a COSY NMR tell you?
Table of Contents
What does a COSY NMR tell you?
¹H-¹H Correlation Spectroscopy (COSY) shows the correlation between hydrogens which are coupled to each other in the ¹H NMR spectrum. The ¹H spectrum is plotted on both 2D axes. The cross-peaks (not on the diagonal) that are symmetric to the diagonal show the COSY correlations.
How do you predict COSY NMR?
Predict 2D NMR COSY (Correlation spectroscopy). Draw your molecule or drop your molfile directly on the editor, then click the simulate button….10.1016/j.jmr.2010.12.008.
| Auto (COSY) coupling | |
|---|---|
| Minimal number of bonds | 0 1 2 3 4 5 6 |
| Maximal number of bonds | 0 1 2 3 4 5 6 |
| Peak width in ppm | |
| Peak height in ppm |
What is the difference between COSY and Noesy?
For example, the presence of a cross peak (a correlation off the diagonal) on a COSY dataset is a result of nuclei coupling through a bond(s) whereas a NOESY dataset measures NOE’s (Nuclear Overhauser Effect) through space regardless of the number of bonds separating the nuclei.
What is the difference between COSY and Tocsy?
In this case, there are two spin systems (one on either side of the carbonyl group). The COSY spectrum shows correlations between adjacent spins whereas the TOCSY spectrum shows correlations between all of the spins in each of the two spin systems.
What is indicated by a cross peak in the COSY spectrum of a compound?
Those peaks indicate which hydrogens are coupled to which other hydrogens. The hydrogens at 1.25 ppm are coupled to the ones at 4.2 ppm, and that gives a “cross-peak” at (1.25, 4.20).
How do I open a Mestrenova file?
Use ctrl-O or to bring up a GUI that will help you navigate and open the data file.
How many proton NMR signals are obtained for CH3CH2OH?
three NMR signals
Ethanol (CH3CH2OH), for example, gives three NMR signals, one of which is due to its OH proton.
How does DEPT NMR work?
DEPT is a polarization-transfer experiment in which the relaxation is governed by the T1 of the protons instead of the carbons. That is notable since the T1 relaxation time of protons is generally much shorter than that of the carbon 13 nuclei. So you may be able to save time with a DEPT NMR experiment.