What are some things that influence the rate of metabolism of caffeine?

It has been known for decades that the metabolism, clearance, and pharmacokinetics of caffeine is affected by many factors such as age, sex and hormones, liver disease, obesity, smoking, and diet.

What enzyme breaks down caffeine?

Caffeine is almost completely metabolized in the body by cytochrome P450 1A2 (CYP1A2). This enzyme accounts for the metabolism of caffeine to its principal metabolite, paraxanthine [1]. In vivo, CYP1A2 activity exhibits a significant degree of inter-individual variation (see [2] for review).

What does it mean if you metabolize caffeine slowly?

If you are a Slow Metabolizer then your genetic makeup indicates you process caffeine at a slower rate and, as a result, caffeine may have longer-lasting stimulant effects. Slow metabolizers may experience negative side effects of caffeine consumption to a higher degree such as insomnia, anxiety, and upset stomach.

Does exercise metabolize caffeine faster?

Exercise raised the maximal plasma caffeine concentrations (R: 7.28: E: 10.45) and reduced both the half-life (R 3.99 h: E 2.29 h) and the volume of distribution (R 37 l: E 20.9 l). Both during exercise and at rest. HD had a greater half-life elimination and volume of distribution than LD.

Do some people metabolize coffee faster?

The science behind coffee consumption CYP1A2 is a gene. People with one or two copies of CYP1A2 (a.k.a. the “slow” gene) metabolize caffeine slowly, while people carrying one or two copies of the “fast” gene metabolize caffeine more quickly.

How can I slow down my caffeine metabolism?

Eating may slow the release of caffeine into your bloodstream. Opt for slow-digesting, fiber-rich foods, such as whole grains, beans, lentils, starchy vegetables, nuts, and seeds ( 1 ).

How long does 80mg of caffeine last?

It reaches a peak level in your blood within 30 to 60 minutes. It has a half-life of 3 to 5 hours. The half-life is the time it takes for your body to eliminate half of the drug.