What does a Michael reaction form?

The Michael reaction is a 1,4-addition (conjugate addition) of enolates to an alpha-beta unsaturated alkene. After we do the addition, we form an enolate – so adding acid gives us the neutral product.

Why is Michael addition important?

The Michael addition forms a carbon–carbon bond, and is thus an important reaction for organic synthesis.

Which of the following is considered a Michael donor?

The nucleophile is called the Michael Donor and the electrophile (the alpha,beta-unsaturated carbonyl) is called the Michael Acceptor.

Which compound below can act as a Michael acceptor?

Michael acceptors: Not only α,β-unsaturated ketones, however, and also esters; nitriles; sulfones; and compounds with activated double bonds can act as Michael acceptors. Vinyl ketones, alkyl acrylates, acrylo nitrile, fumarates etc., are some examples.

When was the Michael reaction discovered?

1887
In 1887, Michael first reported on the reaction that bears his name. Michael’s early work, which began after his return to Hofmann’s laboratory, seemed to be focused on various separate problems in preparative and structural organic chemistry.

What is a Michael acceptor inhibitor?

Aza-peptide Michael acceptors are a new class of irreversible inhibitors that are highly potent and specific for clan CD cysteine proteases. The aza-Asp derivatives were specific for caspases, while aza-Asn derivatives were effective legumain inhibitors.

What type of inhibitor is N3?

Here, we simulate the inhibition process of SARS-CoV-2 Mpro with a known Michael acceptor (peptidyl) inhibitor, N3. The free energy landscape for the mechanism of the formation of the covalent enzyme-inhibitor product is computed with QM/MM molecular dynamics methods.

What is Michael acceptor inhibitor?

What is papain like protease?

The papain-like protease PLpro is an essential coronavirus enzyme that is required for processing viral polyproteins to generate a functional replicase complex and enable viral spread1,2.

What is aza Michael addition?

Aza-Michael reaction is a simple and accessible addition reaction performed at moderate temperature, possibly without a catalyst and without releasing by-products. Its versatility allows designing specific structures thanks to the availability of a multitude of Michael acceptors and Michael donors.

What are poly proteins?

Polyproteins are chains of covalently conjoined smaller proteins that occur in nature as versatile means to organize the proteome of viruses including HIV.