Does sumatriptan affect your heart?

Heart problems: Sumatriptan works by constricting blood vessels, so it may not be suitable for people with heart conditions. Sumatriptan can worsen coronary artery disease (ischemia) or provoke a heart attack (myocardial infarction) or Printzmetal’s angina (coronary artery vasospasm).

Do triptans affect the heart?

Triptans Can Pose Heart Concerns Triptans narrow (constrict) blood vessels in the brain. For most people, these drugs are well tolerated and safe. But triptans also temporarily narrow blood vessels leading to the heart — by 10\% to 20\%, Tepper tells WebMD.

When should you not take sumatriptan?

do not take sumatriptan if you have taken any of the following medications in the past 24 hours: other selective serotonin receptor agonists such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), or zolmitriptan (Zomig); or ergot-type medications such as …

Why should you not take sumatriptan?

Taking too much sumatriptan may make you very ill. An overdose can cause fainting, slowed heart rate, vomiting, loss of bladder and bowel control, and sleepiness. It can narrow your blood vessels leading to heart problems such as chest pains, abnormal heart rhythm or a heart attack.

Can migraine medication cause heart problems?

It is estimated that triptans (sumatriptan, rizatriptan, and all others in this drug grouping), as well as DHE, can narrow heart blood vessels by 18\%. While this is a minor narrowing for a person with normal heart vessels, in those with cholesterol build up, it can become significant.

Can Ajovy cause heart problems?

Based on the data on cardiovascular safety in clinical studies there is no clear trend or signal that suggests an increased risk of cardiac disorders in patients with fremanezumab.

Why is sumatriptan contraindicated in CAD?

Conclusions. This overview suggests that triptans may not be absolutely contraindicated in migraine patients with prior ischemic stroke or CAD. This is due to the pathophysiology of vascular diseases, in which vasoconstrictive mechanisms play no role.

Who should avoid sumatriptan?

People who have ever had a stroke or mini stroke (transient ischaemic attack or TIA). People with very high or uncontrolled high blood pressure (hypertension). People with severe liver problems. People who have taken a monoamine-oxidase inhibitor antidepressant (MAOI) in the last 14 days.

Can sumatriptan cause liver damage?

Sumatriptan (applies to Imitrex) liver disease Major Potential Hazard, High plausibility. The manufacturer considers the use of sumatriptan to be contraindicated in patients with severe hepatic impairment. Sumatriptan is primarily metabolized by the liver.

Can sumatriptan cause strokes?

In several studies, triptan treatment is not associated with increased risk of stroke, even in the setting of overuse [111,115]. Sumatriptan, the prototype of triptan, has once been reported to cause cerebral infarction in a patient with sinus thrombosis [116].

Can Ajovy cause heart palpitations?

I took the Ajovy in April & May 2020. In June 2020, I started to experience GI problems, such as bloating, extreme constipation, nausea, heart palpitations, sense of unease and panic, vertigo, joint pain and extreme fatigue.