How do oncolytic adenoviruses work?

Oncolytic viruses replicate and spread inside tumors, amplifying their cytotoxicity and simultaneously reversing the tumor immune suppression. Among different viruses, recombinant adenoviruses designed to replicate selectively in tumor cells have been clinically tested by intratumoral or systemic administration.

Are adenoviruses oncolytic?

In this therapy, viruses are engineered to selectively propagate in tumor cells and reduce toxicity for non-neoplastic tissues. Adenovirus is one of the most frequently employed oncolytic viruses because of its capacity in tumor cell lysis and immune response stimulation.

How does rexin G work?

The tumor-targeted gene therapy, known as DeltaRex-G (formerly Rexin-G), works by delivering a retroviral vector to tumor cells that encodes for an anticyclin G1 construct that is meant to inhibit the cyclin G1 gene (CCNG1), leading to cell death.

Is leatherette same as Rexine?

Leatherette is a form of artificial leather, usually made by covering a fabric base with plastic. Rexine is the registered trademark of an artificial leather leathercloth fabric produced in the United Kingdom by Rexine Ltd of Hyde.

Who made glybera?

Amsterdam-headquartered firm uniQure developed the drug for a small subset of patients with the rare familial lipoprotein lipase deficiency (LPLD), and gained a five year marketing authorisation to market the drug in the European Union in 2012.

Is Nappa leather genuine leather?

Napa leather is real leather. To be more specific it comes from either full grain or top grain leather. For additional information, Nappa leather is not “genuine leather” even if genuine leather is real leather. By definition, genuine leather comes from any layer of animal skin.

Why is Glybera so expensive?

The drug, Glybera, was the most expensive prescription medication in history at $1 million for a one-time round of injections (see “The World’s Most Expensive Medicine Is a Bust”). It contains engineered viruses carrying copies of a gene meant to correct lipoprotein lipase deficiency, a rare metabolic disease.

What is lipoprotein lipase deficiency?

Familial Lipoprotein Lipase Deficiency – NORD (National Organization for Rare Disorders) Rare Disease Centers of Excellence.