How much does hydroxyzine prolong QT interval?
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How much does hydroxyzine prolong QT interval?
A cumulative review of case reports from the sponsor pharmacovigilance safety database, using a narrow SMQ for QT prolongation and/or TdP, identified 59 case reports potentially linked to hydroxyzine treatment up to 1st August 2016, with an average reporting rate of 3.81 QT prolongation and/or TdP events/1,000,000 …
Can hydroxyzine HCL 25 mg be cut in half?
Swallow the tablet whole. Do not break, crush, or chew it.
What are the side effects of hydroxyzine 25 mg?
Drowsiness, dizziness, blurred vision, constipation, or dry mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.
Can taking hydroxyzine cause heart problems?
Hydroxyzine can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS.
Is Atarax safe for heart patients?
Information to healthcare professionals Hydroxyzine has the potential to block hERG channels and other types of cardiac channels, resulting in a potential risk of QT interval prolongation and cardiac arrhythmia events. This potential risk was confirmed by clinical and post-marketing data.
How much hydroxyzine is safe?
Adults—50 to 100 milligrams (mg) 4 times a day. Children 6 years of age and older—50 to 100 mg per day, divided in small doses. Children younger than 6 years of age—50 mg per day, divided in small doses.
Does hydroxyzine affect heart rate?
Hydroxyzine has the potential to block hERG channels and other types of cardiac channels, resulting in a potential risk of QT interval prolongation and cardiac arrhythmia events. This potential risk was confirmed by clinical and post-marketing data.
What are the dangers of hydroxyzine?
Hydroxyzine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- dry mouth.
- constipation (especially in older adults)
- confusion (especially in older adults)
- dizziness.
- headache.
Does hydroxyzine cause QT prolongation?
The review concluded that hydroxyzine is associated with a small risk of QT interval prolongation and Torsade de Pointes. Such events are most likely to occur in patients who already have risk factors for QT prolongation, such as: concomitant use of medicines that prolong the QT interval.