What are nanostructured lipid carriers NLC and their advantages over SLNs?

NLCs can more strongly immobilize drugs and prevent the particle from coalescing by virtue of the solid matrix compared to emulsions. NLCs also have the advantages of SLNs including low toxicity, biodegradation, drug protection, slow release and avoidance of organic solvents in production (Liu and Wu 2010. 2010.

What are advantages of the SLNs compared to other drug delivery systems?

The great deal of interest focused on SLNs has been due to their many advantages compared to other colloidal systems, including increased drug bioavailability and stability, adjustable technological properties, ability to control and/or to target drug delivery, low production cost, and ease scale-up [6, 7].

What is the difference between SLN and NLC?

… In the aim of enhancing the loading capacity of SLN, a second generation of lipid nanoparticles was developed in 1999; so called nanostructured lipid carriers (NLC) in which the matrix is composed not only of a solid lipid, but of a blend of a solid and a liquid lipid oil, as illustrated in Fig. 7.

What are nanostructured lipid carriers?

Nanostructured lipid carriers (NLCs) are drug-delivery systems composed of both solid and liquid lipids as a core matrix. The related patents of NLCs for drug delivery are also reviewed. Finally, the future development and current obstacles needing to be resolved are elucidated.

What is the advantage of solid lipid nanoparticles?

Lipid nanoparticles have many advantages in comparison to other particulate systems such as the ease of large-scale production(3), biocompatible and biodegradable nature of the materials(4), low toxicity potential(5), possibility of controlled and modified drug release(6), drug solubility enhancement and the …

Are lipid nanoparticles toxic?

In this context, lipid nanoparticles have gained ground, since they are generally regarded as non-toxic, biocompatible and easy-to-produce formulations.

Can lipid nanoparticles cross the blood brain barrier?

Solid lipid nanoparticles (SLN) are nanospheres made from biocompatible solid lipids, with unique advantages among drug carriers: they can be used as vehicles to cross the BBB.

How does solid lipid nanoparticles work?

Solid lipid nanoparticles possess a solid lipid core matrix that can solubilize lipophilic molecules. The lipid core is stabilized by surfactants (emulsifiers). All classes of emulsifiers (with respect to charge and molecular weight) have been used to stabilize the lipid dispersion.

How do solid lipid nanoparticles work?

How do you make lipid nanoparticles?

The lipid nuclic acid nanoparticles were prepared from a liquid nanophase containing water and a water miscible organic solvent where both lipid and DNA are separately dissolved by removing the organic solvent, stable and homogeneously sized lipid-nuclic acid nanoparticle (70-100 nm) were formed.