Which antidepressants increase risk of dementia?

3.4. Meta-Analysis. In the main analysis, a total of five studies evaluated the risk between selective serotonin reuptake inhibitor (SSRI) use and development of dementia. SSRI use is significantly associated with an increased risk of dementia when compared with nonuse.

Is Restless Leg syndrome connected to dementia?

RLS-associated behaviors are also important indicators in older adults with dementia and may present as wandering and restlessness, particularly in the evening (Bliwise, 2006).

What antidepressants worsen restless leg syndrome?

Among the various antidepressants, mirtazapine may be associated with higher rates of restless legs syndrome and periodic limb movements. One small study of normal volunteers suggested that venlafaxine may be associated with an increase in restless legs syndrome symptoms and periodic limb movements.

Do antidepressants make dementia worse?

New evidence shows some anti-depressants can raise dementia risk. Certain antidepressants and bladder medications are linked to increased risk of dementia, according to new University of East Anglia research funded by Alzheimer’s Society and published today in the British Medical Journal.

What is the safest antidepressant for the elderly?

SSRIs considered to have the best safety profile in the elderly are citalopram, escitalopram, and sertraline. [16] These have the lowest potential for drug-drug interactions based on their cytochrome P-450 interactions.

Why are dementia patients so restless?

What causes restlessness in people living with dementia? They may be a symptom of the physical changes in the brain caused by dementia. A person may become agitated suddenly because of a change or specific cause, such as increased noise or not being able to do something they previously could.

Does Lexapro make RLS worse?

In several studies, the use of citalopram, escitalopram, fluoxetine, paroxetine, sertraline, bupropion, venlafaxine, duloxetine, and mirtazapine was reported to increase the risk of RLS [10. Restless legs syndrome as side effect of second generation antidepressants.

Does Zoloft give you restless legs?

Mirtazapine has an approximate 30\% chance of inducing RLS symptoms; by comparison, paroxetine, sertraline, and other psychiatric medications only have an approximate 5\% chance of causing RLS symptoms.

Can someone with dementia take antidepressants?

Antidepressants such as sertraline, citalopram, mirtazapine and trazodone are widely prescribed for people with dementia who develop changes in mood and behaviour.