How do amines react with carboxylic acids?

The direct reaction of a carboxylic acid with an amine would be expected to be difficult because the basic amine would deprotonate the carboxylic acid to form a highly unreactive carboxylate. However when the ammonium carboxylate salt is heated to a temperature above 100 oC water is driven off and an amide is formed.

Which carboxylic acid derivatives can also react with amines to produce amides?

Esters can also react with amines or ammonia to form amides. This reaction doesn’t involve acid catalysis, so the first step is nucleophilic attack at the carbonyl carbon.

What are derivatives of carboxylic acid?

The functional groups at the heart of this chapter are called carboxylic acid derivatives: they include carboxylic acids themselves, carboxylates (deprotonated carboxylic acids), amides, esters, thioesters, and acyl phosphates. Cyclic esters and amides are referred to as lactones and lactams, respectively.

Why do amines and carboxylic acids not react with one another to form peptides?

If one amino acid has its amine protected, it can only react via its carboxylic acid. If the other amino acid has its carboxylic acid protected, it can only react via its amino group. As a result, in peptide synthesis, amines are usually protected as carbamates.

How each of the acid derivatives is produced from carboxylic acid?

Carboxylic acids have a hydroxyl group bonded to an acyl group, and their functional derivatives are prepared by replacement of the hydroxyl group with substituents, such as halo, alkoxyl, amino and acyloxy. The carboxylic acid derivatives can all be hydrolyzed to carboxylic acids.

Which one of the following carboxylic acid derivatives is the most reactive?

Alexander A. B, para ethyl benzoyl chloride is the most reactive towards nucleophilic substitution.

How do you name carboxylic acids and its derivatives?

The nomenclature of acid halides starts with the name of the corresponding carboxylic acid. If the corresponding carboxylic acid has an –oic acid or –ic acid ending it is removed and replaced with the ending -oyl followed by the first syllable of the name of the halogen along with an –ide ending.

Which order of reactivity of derivatives of carboxylic acid is correct?

Acid Chloride > Acid Anhydride > Ester > Amide.