What is egaten used for?

Egaten (triclabendazole) is an anthelmintic indicated for the treatment of fascioliasis in patients 6 years of age and older.

How do you take triclabendazole?

Triclabendazole comes as a tablet to take by mouth. It is usually taken every twelve hours for 2 doses. Take triclabendazole with food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

How is Fasciola hepatica treated?

Triclabendazole. Triclabendazole, a benzimidazole compound active against immature and adult Fasciola parasites, is the drug of choice for treatment of fascioliasis. In February 2019, the U.S. Food and Drug Administration (FDA) approved triclabendazole for treatment of fascioliasis in patients at least 6 years of age .

What is the mechanism of action of triclabendazole against Fasciola hepatica adults?

Like other benzimidazoles, the mechanism of action of triclabendazole results from inhibition of microtubule formation. The β-tubulin protein of F. hepatica exhibits species-specific protein changes at position 82 (glutamic acid) and position 91 (threonine), which are unique among nematodes and cestodes.

What does praziquantel treat?

Praziquantel is used to treat schistosomiasis, also known as snail fever or bilharzia, an infection of the urinary tract or bowels, caused by schistosoma (blood fluke), a flatworm parasite.

What is another name for praziquantel?

BILTRICIDE® (praziquantel) is a trematodicide provided in tablet form for the oral treatment of schistosome infections and infections due to liver fluke.

Is Triclabendazole safe?

Triclabendazole is generally regarded as a safe drug, although adverse events (AEs) can occur following treatment [16], [17]. Such events are directly proportionate to intensity of infection and can be classified as systemic or mechanical.

How do you treat liver flukes in cattle?

Treatment of liver flukes in cattle comes down to a few flukicides; albendazole (Valbazen), corsulon (Ivomec Plus), and triclabendazole (Fasinex 240, United Kingdom). The first two flukicides are only effective against mature adult liver flukes.

How is clonorchis sinensis transmitted?

How does one become infected with Clonorchis? The eggs of Clonorchis are ingested by freshwater snails. After the eggs hatch, infected snails release microscopic larvae that then enter freshwater fish. People become infected by eating infected raw or undercooked fish containing the larvae.

Is Fasciola hepatica Monoecious or dioecious?

F. hepatica adult flukes are hermaphrodite; each contains both male and female reproductive organs.

Is Triclabendazole safe in pregnancy?

Triclabendazole Pregnancy and Breastfeeding Warnings The manufacturer makes no recommendation regarding use during pregnancy. US FDA pregnancy category: Not assigned. Risk summary: No data available on use of this drug in pregnant women to inform a drug-related risk.

Is Triclabendazole available in the US?

Introduction. In February 2019, the US Food and Drug Administration (FDA) approved triclabendazole (Egaten, Novartis Pharmaceuticals, East Hanover, NJ, USA) for the treatment of human fascioliasis.