Can Seroquel cause neuroleptic malignant syndrome?

Quetiapine is one of the preferred antipsychotics among elderly because of its safety profile. However, quetiapine has been rarely been associated with the development of neuroleptic malignant syndrome (NMS) among elderly.

What did Seroquel do to my brain?

Quetiapine works by blocking the receptors in the brain that dopamine acts on. This prevents the excessive activity of dopamine and helps to control symptoms of schizophrenia and manic depression.

How common is tardive dyskinesia with Seroquel?

Tardive dyskinesia (TD) is one of the most significant side effects of antipsychotic medications. The average prevalence rate has been estimated to be around 30\% for individuals taking antipsychotic medications.

How long does neuroleptic malignant syndrome last?

In patients who develop neuroleptic malignant syndrome after taking an oral agent, the syndrome may last 7-10 days after discontinuation of the drug. In those who have received depot neuroleptics (eg, fluphenazine), the syndrome may last up to a month.

Is NMS reversible?

The mortality rate of NMS is estimated to be as high as 20\% and the usual cause of death is due to acute renal failure. Fortunately, with early recognition and intervention, it is usually reversible without any serious complications.

How long does it take to get Seroquel out of your system?

A: The Seroquel (quetiapine) half-life is about six hours. This means it stays in your system for about 1.5 days. Age, liver disease, and severe kidney disease can prolong the process of clearing Seroquel from the body.

How do you diagnose neuroleptic malignant syndrome?

The diagnosis is confirmed by the presence of recent treatment with neuroleptics (within the past 1-4 weeks), hyperthermia (temperature above 38°C), and muscular rigidity, along with at least five of the following features: Change in mental status Tachycardia. Hypertension or hypotension.

How soon after treatment with antipsychotic medications is neuroleptic malignant syndrome NMS likely to develop?

Neuroleptic malignant syndrome (NMS) is a rare, but life-threatening, idiosyncratic reaction to neuroleptic medications that is characterized by fever, muscular rigidity, altered mental status, and autonomic dysfunction. NMS often occurs shortly after the initiation of neuroleptic treatment, or after dose increases.