Do proton pump inhibitors increase the risk of dementia?

showed an increased dementia risk with PPIs use (HR 1.29; 95\% CI 1.12–1.49). In subgroup analyses, a significant association was detected between PPI use and the risk of dementia in Europe (HR 1.46; 95\% CI 1.23–1.73) and among participants aged ≥ 65 years (HR 1.39, 95\% CI 1.17–1.65).

Do proton pump inhibitors cause Alzheimers?

Although the association between PPI use and risk of dementia is contradictory, there are some possible mechanisms that PPI use may contribute to dementia. First, PPIs may affect amyloid-beta (Aβ) metabolism, one of the pathological markers of Alzheimer’s disease (AD).

Are proton pump inhibitors safe for long term use?

However recent studies have potentially linked long term use of PPIs to some systemic severe adverse effects like increased risk of osteoporosis-related fractures, Clostridium difficile infection, malabsorption of vitamins and minerals such as vitamin B12, calcium and iron, dementia, pneumonia, kidney disease, and …

Does omeprazole lead to dementia?

Three studies have found a positive association between dementia and omeprazole, esomeprazole, lansoprazole, and pantropazole, with an approximately 1.4-fold increased risk of any dementia in cohorts using PPIs (95\% CI, 1.36–1.52; P < 0.001) [76].

Why are PPIs bad for elderly?

PPI use in the elderly has been shown to lead to a number of health concerns. Recent data have shown that PPI use is associated with an increased risk of fracture (hip, spine, or wrist fracture, primarily in adults >50 years of age; the greatest risk occurs with high doses or long-term use [>1 year]).

Does PPI cause memory loss?

Millions of people around the world use acid suppressants called proton pump inhibitors for conditions like heartburn, gastritis and stomach ulcers. Researchers at Karolinska Institutet in Sweden now report that how the long-term use of these drugs could increase the risk of developing dementia.

How long can you take a proton pump inhibitor?

PPIs are generally supposed to be taken for two to eight weeks, depending on the condition being treated. Doctors sometimes prescribe PPIs for a longer period of time. The U.S. Food and Drug Administration states that over-the-counter PPIs should only be taken for a single 14-day treatment once every four months.

What are long term side effects of omeprazole?

Long term side effects

• bone fractures.
• gut infections.
• vitamin B12 deficiency – symptoms include feeling very tired, a sore and red tongue, mouth ulcers and pins and needles.

Is long term use of omeprazole safe?

Prilosec (omeprazole) is a proton pump inhibitor that treats severe stomach acid-related conditions like GERD. Common Prilosec side effects include headache, stomach pain and nausea. Long-term Prilosec use has been linked to kidney damage, bone fractures and other dangerous side effects.

What are the risks of long-term use of omeprazole?