Which metabolic pathway do sulfa drugs inhibit?

Inhibition of a Unique Bacterial Metabolic Pathway Sulfonamides and trimethoprim target the folic acid biochemical pathway of bacteria. These antibacterial compounds are termed folic acid pathway inhibitors. Sulfonamides interfere with the formation of folic acid, an essential precursor for nucleic acid synthesis.

What is the mechanism of action of sulfonamide?

Mechanism of Action The sulfonamides inhibit the bacterial enzyme dihydropteroate synthetase (DPS) in the folic acid pathway, thereby blocking bacterial nucleic acid synthesis. Sulfonamides substitute for PABA, preventing its conversion to dihydrofolic acid. Alone, this action is considered bacteriostatic.

What are metabolic pathway inhibitors?

The antibiotics that inhibit the synthesis of metabolites are compounds that resemble a certain metabolite and interferes with the normal metabolism involving that metabolite. …

How do antibiotics inhibit metabolic pathways?

Antibiotics that disrupt essential bacterial metabolic pathways are acting as antimetabolites . These chemicals are structurally similar to natural metabolites but just different enough to interfere with normal cell function.

What is sulfonamide structure?

Structure of Sulfonamides Sulfonamides are composed of a sulfur atom that has two sets of double bonds to two oxygen atoms, a carbon-based side group, and a nitrogen atom bonded to the sulfur itself. In organic chemistry, an amide contains a carbonyl group bonded to a nitrogen atom.

Are sulfonamides broad or narrow spectrum?

Sulfonamides are synthetic, broad-spectrum bacteriostatic antibiotics. Because of associated toxicity and high rates of resistance, their use is now very limited.

What is the mechanism of action of cephalosporin?

Cephalosporins possess a mechanism of action identical to penicillins: inhibition of bacterial cell wall peptidoglycan synthesis by inhibition of penicillin-sensitive enzymes (transpeptidases, carboxypeptidases) that are responsible for the final three-dimensional structure of the rigid bacterial cell wall.

What distinguishes a linear metabolic pathway from a cyclic metabolic pathway?

What distinguishes a linear metabolic pathway from a cyclic metabolic pathway? A linear pathway runs straight in one direction from reactant to product. Which of the following compounds can diffuse through the lipid bilayer of a cell membrane? Which of the statements about diffusion are true?

Which is an aminoglycoside?

The aminoglycosides are broad-spectrum, bactericidal antibiotics that are commonly prescribed for children, primarily for infections caused by Gram-negative pathogens. The aminoglycosides include gentamicin, amikacin, tobramycin, neomycin, and streptomycin.

Which molecule is a sulfonamide?

Sulfonamide is a functional group (a part of a molecule) that is the basis of several groups of drugs, which are called sulphonamides, sulfa drugs or sulpha drugs. The original antibacterial sulfonamides are synthetic (nonantibiotic) antimicrobial agents that contain the sulfonamide group.