Why streptomycin is not used in TB treatment?

Streptomycin was the first effective antituberculosis drug but is no longer a first-line drug as it has the disadvantage that it is not absorbed from the intestine and must therefore be given by intramuscular injection.

When do you give streptomycin in TB?

Streptomycin is administered via injection daily or 5 days a week during the intensive phase, in the first two months of treatment. How it works: Streptomycin is derived from the actinobacteriumStreptomyces griseus. It inhibits protein synthesis and causes the death of microbial cells.

Who should not take streptomycin?

The risk is higher if you have kidney disease, if you are receiving high doses of this medication, if you use this drug for a long time, if you are an older adult (older than 60 years), or if you develop a severe loss of body water (become dehydrated).

What is streptomycin injection for?

STREPTOMYCIN (strep toe MYE sin) is an aminoglycoside antibiotic. It is used to treat certain kinds of bacterial infections. It will not work for colds, flu, or other viral infections.

How does streptomycin cure tuberculosis?

Streptomycin is the most effective antibacterial agent known for tuberculosis. In vitro it has a marked bacteriostatic action on the tubercle bacillus, and in vivo it tends to exert a deterrent effect on the disease in both animals and man.

Why is streptomycin given instead of ethambutol?

Pyrazinamide is only active in an acid environment. Streptomycin is bactericidal against rapidly multiplying TB bacilli. Ethambutol and thiocetazone are used in association with more powerful drugs to prevent the emergence of resistant bacilli.

How many days can I take streptomycin injection?

A minimum of 10 days of therapy is recommended. 4. BACTERIAL ENDOCARDITIS: Streptococcal endocarditis; in penicillin-sensitive alpha and non-hemolytic streptococcal endocarditis (penicillin MIC ≤0.1 mcg/mL), streptomycin may be used for 2-week treatment concomitantly with penicillin.

What happens if streptomycin is given IV?

Streptomycin is administered by deep intramuscular injections and, in both Europe and the USA, the manufacturers do not recommend intravenous administration. However, repeated intramuscular injections of streptomycin produce pain and inflammation.

Can streptomycin cause hearing loss?

Streptomycin may cause nerve damage or hearing loss, especially if you have kidney disease or use certain other medicines. Tell your doctor right away if you have severe dizziness, hearing problems, vision problems, balance problems, trouble concentrating, muscle weakness, numbness, or tingling.

How many days should I take streptomycin?

3. PLAGUE: Two grams of streptomycin daily in two divided doses should be administered intramuscularly. A minimum of 10 days of therapy is recommended.

How long should I take streptomycin?

Some infections may need to be treated with streptomycin for several weeks. Follow your doctor’s dosing instructions very carefully. Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication.

Why is streptomycin so effective?

Streptomycin is an effective antibiotic because its structure is similar to that of the anticodons that would usually bind to the ribosome. Streptomycin is significant because it was the first antibiotic that could treat tuberculosis. Over time, bacteria have become resistant to streptomycin.