How is disseminated superficial actinic Porokeratosis treated?

Often misdiagnosed as chronic UV-damage or actinic keratoses, patients are treated for years with different therapeutic options with little success. Current treatment options include imiquimod, ingenol mebutate, cryosurgery, photodynamic therapy and topical or systemic therapy with retinoids.

Can porokeratosis be cured?

There is no known cure for porokeratosis and treatment is generally disappointing. However, the appearance may improve with the following measures: 5-fluorouracil cream. Calcipotriol cream.

What is disseminated superficial actinic Porokeratosis DSAP?

Disseminated superficial actinic porokeratosis (DSAP) is a skin condition that causes dry, scaly patches.[8488] Symptoms include a large number of small, brownish patches with a distinctive border, found most commonly on sun-exposed areas of the skin (particularly the lower arms and legs).[8488][8489] DSAP usually …

Is Disseminated superficial actinic Porokeratosis premalignant?

Background: Disseminated superficial actinic porokeratosis (DSAP) is a precancerous skin condition often seen by dermatologists that is characterised by multiple annular hyperkeratotic lesions on sun-exposed areas.

Does DSAP ever go away?

Unfortunately, there is no cure for DSAP. The best way to avoid worsening of this skin condition is to avoid exposure to the sun and regular use of sunblock.

Is DSAP autoimmune?

Sometimes autoimmune diseases or their immunosuppressive treatments have been recognized as trigger factors in its development. In the literature there are cases of Sjogren syndrome [4], dermatomyositis [5], scleroderma [6], and rheumatoid arthritis [7] followed by DSAP.

Is DSAP an autoimmune disease?

What causes DSAP to flare up?

DSAP is thought to be caused by a variety of factors. There is a genetic predisposition, but ultraviolet light exposure is thought to be the main cause. This condition tends to affect sun-exposed areas on people with fair skin who burn easily and tan poorly in the sun.

Is DSAP painful?

DSAP is generally harmless but in very rare cases individuals may be at risk of developing squamous cell carcinomas (SCCs) at the affected site, see Patient Information Leaflet on SCC. This tends to present as an enlarging raised lump within the original DSAP, which may be painful.