Why are polyaromatic hydrocarbons considered as carcinogen?

PAHs, like many other carcinogens, do not themselves react covalently with DNA, but require metabolic activation to reactive species. Thus, they are considered procarcinogens.

What are polynuclear aromatic hydrocarbons which of these compounds is a carcinogen?

The EPA has classified the following seven PAH compounds: benz(a)anthracene, benzo(a)pyrene, benzo(b)fluoranthene, benzo(k)fluoranthene, chrysene, dibenz(ah)anthracene, and indeno(1,2,3-cd) pyrene as probable human carcinogens [67].

Why are polycyclic aromatic hydrocarbons toxic?

Genotoxicity and Carcinogenicity However, metabolism of some PAHs also generates reactive intermediates (e.g., diolepoxides, quinones, hydroxyalkyl derivatives), which are not sufficiently polar to be excreted, they form covalent adducts with nucleic acid and lead to genotoxic effects (Abdel-Shafy and Mansour, 2016).

Why aromatic compounds are carcinogenic?

Aromatic compounds are frequently carcinogenic because their physical molecular structures frequently contain five and six carbon rings.

What are isolated polynuclear hydrocarbons?

A polycyclic aromatic hydrocarbon (PAH) is a hydrocarbon—a chemical compound containing only carbon and hydrogen—that is composed of multiple aromatic rings. The simplest of such chemicals are naphthalene, having two aromatic rings, and the three-ring compounds anthracene and phenanthrene.

What do you mean by polynuclear hydrocarbons?

A polynuclear aromatic hydrocarbon is a hydrocarbon made up of fused aromatic ring molecules. These rings share one or more sides and contain delocalized electrons. Another way to consider PAHs is molecules made by fusing two or more benzene rings.

How aromatic hydrocarbons affect humans?

Polycyclic aromatic hydrocarbons (PAHs) are made whenever substances are burned. Breathing smoke or coming into contact with contaminated soil exposes people to PAHs. Some PAHs may cause cancer and may affect the eyes, kidneys, and liver.

What is meant by polynuclear hydrocarbon?

Is naphthalene A PAH?

Polycyclic aromatic hydrocarbons (PAHs) are a class of chemicals that occur naturally in coal, crude oil, and gasoline. Naphthalene is a PAH that is produced commercially in the United States to make other chemicals and mothballs.

Is PAH a carcinogen?

The carcinogenicity of certain PAHs is well established in laboratory animals. Increased incidences of lung, skin, and bladder cancers are associated with occupational exposure to PAHs. Epidemiologic reports of PAH-exposed workers have noted increased incidences of skin, lung, bladder, and gastrointestinal cancers.

What are polynuclear hydrocarbons explain reaction and synthesis of polynuclear hydrocarbons?

polynuclear aromatic hydrocarbon is a hydrocarbon made up of fused aromatic ring molecules. These rings share one or more sides and contain delocalized electrons. Another way to consider PAHs is molecules made by fusing two or more benzene rings. Natural PAHs form from forest fires and volcanic eruptions.