Does PBC cause swelling?

In later stages of PBC, additional symptoms include: Yellowing of the skin and whites of the eyes (jaundice) Swelling of the legs, ankle and feet (edema) Swelling of the abdomen from fluid buildup (ascites)

Is PBC inflammatory?

Primary biliary cholangitis (PBC) is inflammation with progressive scarring of the bile ducts in the liver. Eventually, the ducts are blocked, the liver becomes scarred, and cirrhosis and liver failure develop.

Can primary biliary cirrhosis cause weight gain?

Weight gain is a possible side effect of UDCA. People gain an average of 2.3kg (5lbs) during the first year of taking the medicine, although there’s not usually any more weight gain after this. Other side effects can include diarrhoea, feeling and being sick, and thinning hair.

What does bridging fibrosis mean?

Liver fibrosis occurs when repetitive or long-lasting injury or inflammation causes excessive amounts of scar tissue to build up in the organ. Most types of chronic liver disease can eventually cause fibrosis. Unlike healthy liver cells, scar tissue cells cannot self-repair or otherwise function.

Is PBC considered a rare disease?

Although PBC is considered a rare disease, it is also the most common chronic cholestatic liver disease in adult women. As many as 1 in 1000 women over the age of 40 have PBC. PBC may also run in families, so you might be at greater risk if you have a parent, sibling, or child who has been diagnosed with PBC.

Is PBC a serious disease?

PBC is chronic and progressive. It’s not curable, and over time it can lead to permanent liver damage. However, PBC usually develops slowly. That means you may be able to live normally for many years without any symptoms.

Is PBC painful?

PBC may progress slowly and many people do not have symptoms, particularly in the early stages of the disease. The most common initial symptoms are fatigue and itching of the skin (pruritus). Other symptoms may include: Abdominal pain.

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