Is propranolol a weak acid or base?

Background and purpose of the study: Propranolol HCl, a widely used drug in the treatment of cardiac arrhythmias and hypertension, is a weak basic drug with pH-dependent solubility that may show release problems from sustained release dosage forms at higher pH of small intestine.

Is hydrochloride a strong or weak acid?

HCl is a strong acid because it dissociates almost completely. By contrast, a weak acid like acetic acid (CH3COOH) does not dissociate well in water – many H+ ions remain bound-up within the molecule.

Is a pH of 9 weak base?

The pH of a weak base falls somewhere between 7 and 10.

What is the pKa of propranolol?

Structure for Propranolol hydrochloride (DBSALT000549)

Property	Value	Source
pKa (Strongest Acidic)	14.09	ChemAxon
pKa (Strongest Basic)	9.67	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon

Is propranolol soluble?

Propranolol hydrochloride is a stable, white, crystalline solid which is readily soluble in water and ethanol. Its molecular weight is 295.80.

How do you know if a drug is acidic or basic?

The only sure way to know whether a drug is acidic or basic is to learn the functional groups that confer acidity and basicity on a molecule. This should be done even if it means learning the names of the functional groups the way you learned multiplication tables at primary school.

Is Hydrochloric acid is weak?

HCl is a strong acid because it dissociates almost completely. By contrast, a weak acid like acetic acid (CH3COOH) does not dissociate well in water – many H+ ions remain bound-up within the molecule. In summary: the stronger the acid the more free H+ ions are released into solution.

What is strong base and weak base?

Strong base: A base which completely ionises in water and produces a large amount of hydroxide ions. Weak base: A base which is partially ionised in water and produces a small amount of hydroxide ions.

What is the relation between pKa and pH?

There is a simple relation between pH and pKa , pH = 1 2[pKa − logc] where c is concentration of the acid. You can derive this relation using Ostwald’s dilution law. Similarly, we have Kb, pKb and pOH for bases which are basic analogues of Ka, pKa and pH. These variables show the strength of a base.

What is propranolol hydrochloride?

More… Propranolol Hydrochloride is the hydrochloride form of propranolol, a synthetic beta-adrenergic receptor blocker with antianginal, antiarrhythmic, and antihypertensive properties.

Is propranolol a competitive beta blocker?

Propranolol is classified as a competitive non-cardioselective sympatholytic beta blocker that crosses the blood–brain barrier. It is lipid soluble and also has sodium channel blocking effects.

What is the difference between P K a < 3 and 7?

p K a < 3 is for a strong acid. 3 < p K a < 7 is for a weak acid. 7 < p K a < 11 is for a weak base. p K a > 11 is for a strong base. physical-chemistry acid-base ph. Share. Improve this question. edited Oct 2 ’15 at 23:17. user7951.