What antibiotic class is mupirocin?

Mupirocin is in the carboxylic acid class of medications. It works by blocking a bacteria’s ability to make protein, which usually results in bacterial death.

What does mupirocin do to bacteria?

Unlike most other antibiotics that act on either bacterial DNA or the walls of bacteria, mupirocin blocks the activity of an enzyme called isoleucyl-tRNA synthetase within the bacteria. This enzyme is necessary in order for the bacteria to make proteins. Without the ability to make proteins, the bacteria die.

What is the mechanism of action of topical antibiotics?

The main mechanism of action of topical antibiotics for acne treatment is inhibition of inflammation caused by bacteria rather than a direct bactericidal effect.

What is the mechanism of action of bacitracin?

Bacitracin is a polypeptide antibiotic derived from B. subtilis that functions to block cell wall formation by interfering with the dephosphorylation of the lipid compound that carries peptidoglycans to the growing microbial cell wall.

Is mupirocin a topical antibiotic?

What is mupirocin topical? Mupirocin is an antibiotic that prevents bacteria from growing on your skin. Mupirocin topical (for use on the skin) is used to treat skin infections such as impetigo (IM-pe-TYE-go) or a “Staph” infection of the skin.

What is the mechanism of action of metronidazole?

Mechanism of Action Metronidazole diffuses into the organism, inhibits protein synthesis by interacting with DNA and causing a loss of helical DNA structure and strand breakage. Therefore, it causes cell death in susceptible organisms.

What skin conditions does mupirocin treat?

What Conditions does MUPIROCIN Treat?

• methicillin-resistant Staphylococcus aureus bacteria in nose.
• furunculosis or boils on the skin.
• a type of bacterial skin infection called impetigo.
• inflammation of a hair follicle.
• minor skin infection due to bacteria.

What infections does mupirocin treat?

Mupirocin is an antibiotic that prevents bacteria from growing on your skin. Mupirocin topical (for use on the skin) is used to treat skin infections such as impetigo (IM-pe-TYE-go) or a “Staph” infection of the skin. Mupirocin topical may also be used for purposes not listed in this medication guide.

What bacteria does mupirocin cover?

The antimicrobial spectrum for mupirocin includes staphylococci (MRSA, MSSA), streptococci, anaerobes, and Enterobacteriaceae. The primary use of mupirocin is as a topical application for skin infections, such as impetigo due to S. aureus or S. pyogenes.

What are the modes of action for bacitracin and tetracycline?

Learning Objectives

Table 1. Common Antibacterial Drugs by Mode of Action
Mode of Action	Target	Drug Class
Inhibit cell wall biosynthesis	Peptidoglycan subunits	Glycopeptides
Peptidoglycan subunit transport	Bacitracin
Inhibit biosynthesis of proteins	30S ribosomal subunit	Aminoglycosides, tetracyclines

What is the mode of action of erythromycin?

Erythromycin acts by inhibition of protein synthesis by binding to the 23S ribosomal RNA molecule in the 50S subunit of ribosomes in susceptible bacterial organisms.

What is the spectrum of action of metronidazole?

The nitroimidazole antibiotic metronidazole has a limited spectrum of activity that encompasses various protozoans and most Gram-negative and Gram-positive anaerobic bacteria.