What happens if you take PPI for a long time?

Recent studies, however, have cited dangers thought to be associated with the long-term use of PPIs. Among them: an increased risk of kidney disease, osteoporosis, low magnesium or vitamin B12 in the blood, pneumonia, stroke, and contracting the Clostridium difficile (C. diff) bacterium.

What is considered long term use of a PPI?

In a clinical context, use of PPI for more than 8 weeks could be a reasonable definition of long-term use in patients with reflux symptoms and more than 4 weeks in patients with dyspepsia or peptic ulcer.

Can taking omeprazole long term cause problems?

Long term side effects Taking omeprazole for more than a year may increase your chances of certain side effects, including: bone fractures. gut infections. vitamin B12 deficiency – symptoms include feeling very tired, a sore and red tongue, mouth ulcers and pins and needles.

Do all PPIs have the same side effects?

In general, PPIs are believed to have few adverse effects, as they are generally well tolerated. Patients have experienced few minor side effects of short-term PPI use, such as headache, rash, dizziness, and gastrointestinal symptoms including nausea, abdominal pain, flatulence, constipation, and diarrhea.

Can PPIs cause nerve damage?

Furthermore, we found significant associations of PPI use with a wide range of neurological adverse reactions including, migraine, several peripheral neuropathies, and visual and auditory neurosensory abnormalities.

Which complications can occur due to long term use of proton pump inhibitors in patients with gastroesophageal reflux disease?

The long-term consequences of chronic PPI use include the potential increased risk of hypocalcemia, hypomagnesemia, Clostridium difficile infections, and pneumonia.

Can omeprazole cause kidney damage?

In recent years, the use of proton pump inhibitors (PPI), especially omeprazole, has been associated with development of chronic kidney disease (CKD). These drugs are widely used worldwide. Although some studies have found an association between the use of PPI and the onset of acute renal failure and CKD.