What is the difference between solid state NMR and solution NMR?

In solution NMR, spectra consist of a series of very sharp transitions, due to averaging of anisotropic NMR interactions by rapid random tumbling. By contrast, solid-state NMR spectra are very broad, as the full effects of anisotropic or orientation-dependent interactions are observed in the spectrum.

Can you use NMR on solids?

Solid-state nuclear magnetic resonance (NMR) spectroscopy is an atomic-level method to determine the chemical structure, 3D structure and dynamics of solids and semi-solids. This Primer summarizes the basic principles of NMR spectroscopy as applied to the wide range of solid systems.

What instrument is used for NMR?

An NMR spectrometer typically consists of a spinning sample-holder inside a very strong magnet, a radio-frequency emitter, and a receiver with a probe (an antenna assembly) that goes inside the magnet to surround the sample, optionally gradient coils for diffusion measurements, and electronics to control the system.

How do you prepare a sample for solid state NMR?

Sample prep: Solid state NMR is done using ‘rotors’ of various outer diameters (1 mm – 7 mm usually), usually made of zirconia. The solid samples are packed inside these rotors. It is a bit more involved and time-consuming than solution-state sample prep.

What is solid-state NMR used for?

Introduction. Solid state NMR (ssNMR) spectroscopy is an invaluable analytical tool which is used to determine the chemical composition, local structure and dynamic properties of solids.

What is solid state NMR used for?

Why are solid state NMR signals generally much broader than solution state NMR?

For solution state NMR, chemical shift and J-coupling (spin-spin splitting) are the incterations basically influence the resulting spectra. So both of the interactions have significant effect in the solid-state NMR, which results in much more broad peaks instead of narrow peaks in solution-state NMR.

What is NMR probe used for?

The probe is the part of an NMR spectrometer that does much of the work, in terms of exciting the nuclear spins, and detecting the NMR signal. The probe goes into the center of the magnetic field, and the sample is inserted into the probe to perform the NMR experiment.

What is liquid state NMR?

Two-dimensional (2D) liquid-state NMR has a very high potential to simultaneously determine the absolute concentration of small molecules in complex mixtures, thanks to its capacity to separate overlapping resonances.

How does NMR spectroscopy work?

How Does NMR Actually Work? When molecules are placed in a strong magnetic field, the nuclei of some atoms will begin to behave like small magnets. The resonant frequencies of the nuclei are then measured and converted into an NMR spectrum that displays all of the right frequencies as peaks on a graph.

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