What is the Splenium in the brain?

The splenium is the thickest and most posterior portion of the corpus callosum (CC). It consists of numerous axonal fibers that mainly connect both temporal, posterior parietal, and occipital cortices (1).

What is the main function of the corpus callosum?

The two hemispheres in your brain are connected by a thick bundle of nerve fibres called the corpus callosum that ensures both sides of the brain can communicate and send signals to each other.

What are the diseases of corpus callosum?

Disorders of the corpus callosum

• prenatal infections or viruses, such as rubella.
• genetic abnormalities, such as Andermann or Aicardi syndromes.
• toxic metabolic conditions, such as fetal alcohol syndrome (heavy drinking or alcoholism during pregnancy)

What is Genu and Splenium?

The front part of the corpus callosum, that is towards the frontal lobe is called the genu. The thinner part of the corpus callosum is the rostrum. The end part or the posterior part towards the cerebellum is called splenium. The trunk or the body lies between the genu and the splenium.

Is ACC genetic?

Causes. In most cases, the cause of ACC is unknown. However, agenesis of corpus callosum can be inherited as an autosomal recessive trait or an X-linked dominant trait. This disorder may also be due in part to an infection during pregnancy (intrauterine) leading to abnormal development of the fetal brain.

What will happen if the corpus callosum is damaged?

Lesions of any part of the corpus callosum might lead to loss of contact between bilateral hemispheres that cause mental disorders, pseudobulbar palsy, speech and movement ataxia.

What causes thinning of corpus callosum?

Secondary thinning of the corpus callosum can be caused by diffuse injury such as hypoxic-ischemic encephalopathy, human immunodeficiency virus (HIV) encephalopathy, hydrocephalus, dysmyelinating conditions and demyelinating conditions.

Can corpus callosum be cured?

Currently, there are no treatments to restore the corpus callosum to normal. The main course of treatment for agenesis of the corpus callosum is to manage any complications that may arise. Treatment options may include: Medications to control seizures.

What is a callosum?

The corpus callosum is a large, C-shaped nerve fiber bundle found beneath the cerebral cortex. It stretches across the midline of the brain, connecting the left and right cerebral hemispheres. It makes up the largest collection of white matter tissue found in the brain.