Which form of B12 is best absorbed?

Methylcobalamin
Methylcobalamin. Methylcobalamin is the most bio-available type of Vitamin B12 which means the body absorbs it more easily. Naturally occurring, it is found in animal-based foods such as meat, fish, milk and eggs so is readily available in many people’s daily diet.

Is sublingual B12 as effective as injections?

Comparing the sublingual method to vitamin B12 injections, research found that taking B12 under the tongue had a higher absorption rate, making it a better option (Bensky, 2019). Taking vitamin B12 sublingually may also be a good option for people with a condition called pernicious anemia.

Which one is better cyanocobalamin or methylcobalamin?

The body may absorb cyanocobalamin better, while methylcobalamin has a higher retention rate. Both can prevent B12 deficiency, but methylcobalamin should be combined with adenosylcobalamin for best results.

Which sublingual B12 is best?

Sublingual Methyl B12 refers to Vitamin B12 in the methylcobalamin form. It is felt to be superior to cyanocobalamin and the methyl form is better and easier for absorption.

Are B12 injections more effective than tablets?

B12 injections can be more effective than the pills in certain patients who have trouble absorbing vitamin B12. In the majority of patients the pills are just as good as the injections.

Is Hydroxocobalamin the same as cyanocobalamin?

Your haematologist will advise on how long you need to keep taking the injections. For injections of vitamin B12 given in the UK, hydroxocobalamin is preferred to an alternative called cyanocobalamin. This is because hydroxocobalamin stays in the body for longer.

Is cyanocobalamin IM or SUBQ?

Cyanocobalamin is usually administered by IM or deep subcutaneous injection. If the drug is administered subcutaneously, care should be taken to avoid injection into the dermis or upper subcutaneous tissue. Because the drug is excreted more rapidly after IV injection, the IV route should be avoided.

Is B12 effective in pill form?

For many people with low B12 levels, a daily supplement in the form of a pill is as effective as taking a monthly muscle injection. The choice of shot or pill depends on the reason for the deficiency.

Why is Hydroxocobalamin given intramuscularly?

Hydroxocobalamin is a man-made injectable form of vitamin B12 used to treat low levels (deficiency) of this vitamin. Vitamin B12 helps your body use fat and carbohydrates for energy and make new protein. It is also important for normal blood, cells, and nerves.

What is cyanocobalamin B12?

Cyanocobalamin – Synthetic Vitamin B12 As we have discussed, for many years B12 supplements mainly contained cyanocobalamin, a synthetic form of B12 that is not directly bioactive and is only found naturally in the body or diet in minor traces.

What are the treatment options for vitamin B12 deficiency?

Most people with vitamin B12 deficiency are treated in primary care with intramuscular vitamin B12 which is a considerable source of work for health care professionals.

What is the best B12 supplement for You?

Instead of taking a single active ingredient, a combination of all of the natural B12 forms is the optimal solution – as it mirrors the B12 content in foods. The ideal B12 supplement contains a mix of methylcobalamin, hydroxocobalamin and adenosylcobalamin (11).

Is there an alternative to vitamin B12 injections?

Vitamin B12 is also available as a prescription medication in a gel formulation applied intranasally, a product marketed as an alternative to vitamin B12 injections that some patients might prefer [21].