How does vitamin D help your kidneys?
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How does vitamin D help your kidneys?
Healthy kidneys are rich with vitamin D receptors and play a major role in turning vitamin D into its active form. This helps balance calcium and phosphorus in your body by controlling absorption of these minerals from the food you eat and regulates parathyroid hormone (PTH).
How do kidneys convert vitamin D to its active form?
Vitamin D actions require vitamin D activation to its hormonal form, 1,25-dihydroxyvitamin D (calcitriol; 1,25D), by renal and extrarenal 1-hydroxylases to bind and activate the VDR in an endocrine and/or autocrine manner, respectively.
How does vitamin D deficiency affect the kidneys?
Researchers found that those who were deficient in vitamin D were more than twice as likely to develop albuminuria (a type of protein in the urine) over a period of five years. Albuminuria is an early indication of kidney damage as healthy kidneys capture protein for use in the body.
Which cells in the kidney activate vitamin D?
It is well established that the mitochondria of proximal convoluted tubule cells of the kidney are the site of production of circulating 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3]. The production of 1,25(OH)2D3 at this site is tightly regulated.
Is taking vitamin D hard on kidneys?
Taking too much vitamin D can cause problems such as constipation and nausea and, in more serious cases, kidney stones and kidney damage.
Is vitamin D supplement safe for kidneys?
Vitamin D has been reported to have a wide range of benefits. However, a recent case study indicates that excessive use of vitamin D can cause kidney damage in people who are not deficient in the vitamin.
What is the most active form of vitamin D?
Calcifediol is further hydroxylated by the kidneys and some of the immune system cells to form calcitriol (also known as 1,25-dihydroxycholecalciferol), the biologically active form of vitamin D. Calcitriol circulates as a hormone in the blood, having a major role regulating the concentration of calcium and phosphate.
What vitamins help your kidneys?
Special renal vitamins are usually prescribed to kidney patients to provide the extra water soluble vitamins needed. Renal vitamins contain vitamins B1, B2, B6, B12, folic acid, niacin, pantothenic acid, biotin and a small dose of vitamin C.
Does the kidney secrete vitamin D?
The biologically active form of vitamin D3, 1,25-dihydroxycholecalciferol is produced by the kidney. The biosynthesis of 1,25-dihydroxycholecalciferol from 25-hydroxycholecalciferol is apparently controlled and important factors in this control are dietary calcium and phosphorus, and parathyroid hormone secretion.