What are the roles of the ER and Golgi in glycosylation?

Protein glycosylation has multiple functions in the cell. In the ER, glycosylation is used to monitor the status of protein folding, acting as a quality control mechanism to ensure that only properly folded proteins are trafficked to the Golgi.

Which type of glycosylation take place in the Golgi apparatus?

O-linked glycosylation is a form of glycosylation that occurs in eukaryotes in the Golgi apparatus, but also occurs in archaea and bacteria.

What kind of glycosylation occurs in the ER?

Introduction. Glycosylation is a ubiquitous modification of newly synthesized proteins in the endoplasmic reticulum (ER). Dependent on the linkage of the oligosaccharide to the amino acid side chain of the protein there are two major types of glycosylation: N- and O-glycosylation.

What is the difference between the rough ER and the Golgi bodies?

The Golgi body consists of stacks of flattened membrane-enclosed and fluid-filled saccules (cisternae). The rough ER is characterized by fairly flat, sealed sacs which are studded with membrane-bound ribosomes on the outer surface (which is exposed to the cytosol).

What is the difference between glycosylation and Glycosidation?

Glycosylation converts a carbohydrate into a glycoprotein or glycolipid while glycosidation converts a carbohydrate into a glycoside. On the other hand, glycosidation is the formation of a glycoside by forming a glycosidic bond. So, this is the key difference between glycosylation and glycosidation.

What is the difference between glycation and glycosylation?

Glycation is a non-enzymatic reaction, irreversible and concentration-dependent, in which glucose or other carbohydrates are added onto proteins, lipids or DNA. Glycosylation, on the other hand, is a post-translational process in which the addition of carbohydrates to proteins or lipids is catalysed by enzymes.

What is the difference between N linked and glycosylation?

Other major differences in the two types of glycosylation are (1) N-linked glycosylation occurs on asparagine (N) residues within an N-X-S or N-X-T sequence (X is any amino acid other than P or D) while O-linked glycosylation occurs on the side chain hydroxyl oxygen of either serine or threonine residues determined not …

What is N-glycosylation and O glycosylation?

There are two types of protein glycosylation, both of which require import of the target polypeptide into the ER. N-linked glycosylation actually begins in the endoplasmic reticulum, but O-linked glycosylation does not occur until the polypeptide has been transported into the Golgi apparatus.

What is the main difference between rough ER and smooth ER?

The main difference between these two terminologies is that the Smooth Endoplasmic Reticulum is known for stocking the lipids and proteins. It is not bounded by ribosomes. Whereas, the Rough Endoplasmic Reticulum is bounded by the ribosomes and also stores proteins.