What does peak plasma concentration mean?

peak plasma drug concentration. (Science: pharmacology) The highest level of drug that can be obtained in the blood usually following multiple doses.

Why is peak plasma concentration important?

Absorption determines how a drug is taken and its bioavailability into the systemic circulation and therefore the peak plasma concentration and the time to peak plasma concentration of a drug. All these parameters influence the extent and timing of drug action.

How peak plasma concentration is related to minimum effective concentration and maximum safe concentration?

Peak concentration is often related to the intensity of pharmacological response and should ideally be above minimum effective concentration (MEC) but less than the maximum safe concentration (MSC). 2.

What is plasma concentration of drug?

Definition: Plasma concentration refers to the concentration of an agent in the plasma which is derived from full blood. Plasma concentrations are used to define major PK and PK/PD parameters.

What is the peak of a drug?

The peak level is the highest concentration of a drug in the patient’s bloodstream.

What does Tmax mean in medical terms?

T. max. Pharmacology The amount of time that a drug is present at the maximum concentration in serum.

What is plasma concentration of a drug?

“Drug concentration” is derived by collecting a blood sample at any time after drug administration and measuring the amount of a drug in a given volume of blood plasma of the sample. 8. The measured drug concentration is generally known as “plasma concentration.”

What is the peak concentration of a drug?

From Wikipedia, the free encyclopedia. Cmax is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administered and before the administration of a second dose.

What is plasma drug concentration time curve?

The area under the blood (or plasma) concentration–time curve reflects the amount of a xenobiotic that has effectively reached the systemic circulation and as such is influenced both by the degree of bioavailability and by the rate at which a xenobiotic is removed from the body.

How do you read plasma concentration of a drug?

Loading dose (mg) = [Cp (mg/L) x Vd (L)] / F

1. Cp represents the desired plasma concentration of drug.
2. Vd represents the volume of distribution.
3. F represents the bioavailability of drug (IV administration = 1)

What are the main factors that determine plasma concentration?

Likewise, plasma levels will depend on dosage, time and route of drug administration, the bioavailability of the drug and time of blood sampling. In addition, absorption, distribution, metabolism, excretion and concurrent drug administration may profoundly affect plasma drug concentrations.