How do you know if you have a metabolic pathway?

Generally, the metabolic pathways are represented as directed graphs, and the protein-to-protein interaction pathways are represented as undirected graphs. On the other hand, it is possible to identify the path based on enzymes, and subgraphs will be represented as undirected graphs.

What is metabolic pathway analysis?

Metabolic pathway analysis, a methodology used in metabolic pathway modeling, assesses inherent network properties and identifies meaningful structural and functional units in the metabolic networks (Klamt et al. 2003). MPA can be used to study meaningful pathways (routes) and flexibility in metabolic networks.

What characterizes the rate determining step of a metabolic pathway?

What characterizes the rate-determining step of a metabolic pathway? It functions far from equilibrium and it has a large negative free energy change.

What are two ways in which a metabolic pathway can be regulated?

Regulation of metabolic pathways includes regulation of an enzyme in a pathway by increasing or decreasing its response to signals. Control involves monitoring the effects that these changes in an enzyme’s activity have on the overall rate of the pathway.

What are three types of metabolic pathway regulation?

Metabolic regulation is a term used to describe the process by which metabolic pathways (both the anabolic/biosynthetic and catabolic/degradative pathways) are regulated in mammals.

What statistical test is used to calculate the P value for pathway over representation in David or the pathway tool you used?

P-values for each pathway are calculated using a right-tailed Fisher’s exact test based on the hypergeometric distribution.

How biological processes control metabolic pathways?

In order to bolster a particular pathway, cells can increase the amount of a necessary (rate-limiting) enzyme or use activators to convert that enzyme into an active conformation. Such up- and down-regulation of metabolic pathways is often a response to changes in concentrations of key metabolites in the cell.