What determines the absorption ability of a drug?

Drug absorption is determined by the drug’s physicochemical properties, formulation, and route of administration.

What is the difference between drugs administered sublingually and Buccally?

Sublingual administration involves placing a drug under the tongue and buccal administration involves placing a drug between the gums and cheek.

Why sublingual or buccal route avoid first-pass metabolism?

Alternative routes of administration, such as insufflation, suppository, intravenous, intramuscular, inhalational aerosol, transdermal, or sublingual, avoid the first-pass effect because they allow drugs to be absorbed directly into the systemic circulation.

Can all drugs be absorbed sublingually?

Substance. Almost any form of substance may be amenable to sublingual administration if it dissolves easily in saliva. Powders and aerosols may all take advantage of this method. However, a number of factors, such as pH, molecular weight, and lipid solubility, may determine whether the route is practical.

Where do drugs get absorbed?

Oral administration – This includes swallowing pills, drinking a liquid, or eating a substance. In this method of administration, most of the absorption of the substance takes place in the small intestine. The drug will then move to the liver and then back into the bloodstream to be transported to its destination.

What factors affect absorption quizlet?

Drug Absorption

• formulation factors.
• ionization degree.
• size of drug.
• concentration of drug.
• water solubility at site of absorption.
• lipid solubility.
• chemical stability.
• binding of drug to other drugs, foods or particles.

How are drugs absorbed sublingual?

Sublingual administration involves placing a drug under your tongue to dissolve and absorb into your blood through the tissue there. Buccal administration involves placing a drug between your gums and cheek, where it also dissolves and is absorbed into your blood.

How are sublingual medications metabolized?

Medications that are administered sublingually dissolve under the tongue, without chewing or swallowing. Absorption is very quick, and higher drug levels are achieved in the bloodstream by sublingual routes than by oral routes because (1) the sublingual route avoids first-pass metabolism by the liver (Fig.

What affects sublingual absorption?

Eating, drinking, or smoking, can affect how the drug is absorbed and how well it works. Also, these forms don’t work for drugs that need to be processed slowly by your system, such as extended-release formulations. Any open sores in your mouth can also become irritated by the medication.

Why are some drugs given sublingually?

Sublingual administration of drug refers to the placement of drug under the tongue (Rehfeld et al., 2017). The sublingual route bypasses the first-pass metabolism and hence facilitates rapid absorption of the drug into the systemic circulation. Drug directly reaches the systemic circulation using blood vessels.