What is PNI in breast cancer?
What is PNI in breast cancer?
Background: Lymphovascular invasion (LVI) is a poor prognostic feature in breast cancer. Perineural invasion (PNI), a sign of aggressive behavior potential in other tumor systems, is less frequently observed in mammary carcinoma and hence has been less well studied.
How serious is perineural invasion?
Perineural invasion means that cancer cells were seen surrounding or tracking along a nerve fiber within the prostate. When this is found on a biopsy, it means that there is a higher chance that the cancer has spread outside the prostate.
Does perineural invasion mean metastasis?
Perineural invasion (PNI) can be found in a variety of malignant tumors. It is a sign of tumor metastasis and invasion and portends the poor prognosis of patients. The pathological description and clinical significance of PNI are clearly understood, but exploration of the underlying molecular mechanism is ongoing.
What does PNI mean in medical terms?
Perineural invasion (PNI) is a histopathologic diagnosis, while perineural spread (PNS) is a clinical and radiologic diagnosis. PNI in head and neck cancers is well described, and the available evidence suggests it is an adverse feature in terms of risk for locoregional recurrence.
What is the meaning of PNI?
PNI
| Acronym | Definition |
|---|---|
| PNI | Positive, Negative, Interesting (decision making) |
| PNI | Porter Novelli International (public relations; various locations) |
| PNI | Pohnpei, Caroline Islands, Micronesia – Pohnpei International (Airport Code) |
| PNI | Pacific Nanotechnology, Inc. (Santa Clara, CA) |
What is LVI and PNI?
Lymphovascular invasion (LVI) refers to the involvement of small lymphatic or blood (typically venous) vessels by tumor [3]. Perineural invasion (PNI) refers to the growth of tumor in, around, and through nerves and nerve sheaths [4], [5].
What is the meaning of perineural invasion?
Abstract. Perineural invasion (PNI) is the process of neoplastic invasion of nerves and is an under-recognized route of metastatic spread. It is emerging as an important pathologic feature of many malignancies, including those of the pancreas, colon and rectum, prostate, head and neck, biliary tract, and stomach.
What does LVI mean?
LVI stands for lymphovascular invasion. Lymphovascular invasion is the movement of cancer cells into either a blood or lymphatic vessel. Lymphovascular invasion allows cancer cells to spread to lymph nodes or other parts of the body.
What is squamous cell carcinoma well differentiated?
A term used to describe cells and tissue that have mature (specialized) structures and functions. In cancer, well-differentiated cancer cells look more like normal cells under a microscope and tend to grow and spread more slowly than poorly differentiated or undifferentiated cancer cells.