Which antibody is most specific for SLE?

The antinuclear antibody (ANA) test is the most commonly used screening test for SLE. The presence of anti-DNA, anti-Sm, and antiphospholipid antibodies is more specific for diagnosing SLE.

What autoimmune disorder is indicated by an increased titer of anti-SM Anti Smith antibody?

Reference Range. Anti-Smith antibodies are present in some cases of systemic lupus erythematosus (SLE) and mixed connective-tissue disease (MCTD).

Which test is the most specific and sensitive test for SLE?

The antinuclear antibody (ANA) test is the most sensitive test for SLE and is therefore the best screening assay for ruling out its presence. Anti-native (N)-DNA and anti-Sm (Smith antigen) tests are highly specific for SLE and have strong confirmatory powers, even in a patient unlikely to have the disease.

What is anti-Smith antibody?

Background: Anti-Smith (Sm) antibody is a highly specific antibody for systemic lupus erythematosus (SLE). Despite the remarkable specificity of anti-Sm antibodies for SLE, the association between anti-Sm antibody level and the clinical manifestation of SLE is still unclear.

What does anti Smith antibody target?

These anti-Sm autoantibodies individually target a number of components of the spliceosome, namely Sm B (26 kDa), B′ (27 kDa), D1 (16 kDa), D2 (16.5 kDa), D3 (18 kDa), E/F (11 kDa doublet), and G (<10 kDa). Protein sequences of Sm B, B′, D1, D2, D3, and E have been known for some time.

What is anti Smith antibody?

What is a normal range for Smith antibody?

Reference Interval

Test Number	Components	Reference Interval
0050470	Smith/RNP (ENA) Antibody, IgG	19 Units or less Negative 20-39 Units Weak Positive 40-80 Units Moderate Positive 81 Units or greater Strong Positive
0050085	Smith (ENA) Antibody, IgG	29 AU/mL or less Negative 30-40 AU/mL Equivocal 41 AU/mL or greater Positive

Does anti Smith mean lupus?

Background: Anti-Smith (Sm) antibody is a highly specific antibody for systemic lupus erythematosus (SLE).

Can you have lupus with negative anti-Smith?

This is because by itself, the test has low diagnostic specificity for systemic lupus, but its value increases as a patient meets other clinical criteria. It is possible for people with lupus to have a negative ANA, but these instances are rare.