What cells are affected by Klinefelter syndrome?
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What cells are affected by Klinefelter syndrome?
Klinefelter syndrome is a sex chromosome disorder in boys and men that results from the presence of an extra X chromosome in cells. People typically have 46 chromosomes in each cell, two of which are the sex chromosomes. Females have two X chromosomes (46,XX), and males have one X and one Y chromosome (46,XY).
How does Klinefelter syndrome work?
Klinefelter syndrome isn’t passed down through families like some genetic diseases. Instead, it happens randomly from an error in cell division when a parent’s reproductive cells are being formed. If one of these cells is part of a successful pregnancy, a baby boy will have the XXY condition.
What chromosome does Klinefelter affect?
Klinefelter syndrome is caused by an additional X chromosome. This chromosome carries extra copies of genes, which interfere with the development of the testicles and mean they produce less testosterone (male sex hormone) than usual.
How does Klinefelter syndrome occur in meiosis?
In 1959, Klinefelter syndrome was found to be caused by a supernumerary X chromosome in a male. The 47,XXY karyotype of Klinefelter syndrome spontaneously arises when paired X chromosomes fail to separate (nondisjunction in stage I or II of meiosis, during oogenesis or spermatogenesis).
What organs are affected by Klinefelter syndrome?
Klinefelter syndrome may adversely affect testicular growth, resulting in smaller than normal testicles, which can lead to lower production of testosterone. The syndrome may also cause reduced muscle mass, reduced body and facial hair, and enlarged breast tissue.
Many boys with Klinefelter syndrome show symptoms related to their development of social and language skills. They may have trouble paying attention. A lot of boys learn to talk late or have trouble using words to express their emotions. They also can have trouble with things like learning to spell, read, and write.
What chromosome does Angelman syndrome affect?
Angelman syndrome is a genetic disorder. It’s usually caused by problems with a gene located on chromosome 15 called the ubiquitin protein ligase E3A (UBE3A) gene.
What is the genotype of Klinefelter syndrome?
In Klinefelter syndrome, the person has an extra X chromosome which results in three sex chromosomes (2X chromosomes and a Y chromosome). This results in a genotype of 44 + XXY or 47 chromosomes.
Is Klinefelter syndrome mitosis or meiosis?
Klinefelter’s syndrome, XXY males, can occur due to nondisjunction of X chromosomes during prophase of meiosis I in females. One of the eggs from such a meiosis could receive both X chromosomes, and the other would receive no X chromosomes.
Does Klinefelter’s occur in meiosis 1 or 2?
The most frequent chromosomal complement associated with Klinefelter syndrome is 47,XXY, which may result from a nondisjunction during (1) meiosis I or meiosis II of oogenesis, or (2) meiosis I of spermatogenesis.
What happens if XXY?
As XXY males enter puberty, they often don’t make as much testosterone as other boys. This can lead to a taller, less muscular body, less facial and body hair, and broader hips than other boys. As teens, XXY males may have larger breasts, weaker bones, and a lower energy level than other boys.